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Review
. 2005 Aug 29;24(37):5764-74.
doi: 10.1038/sj.onc.1208927.

TGF-beta and epithelial-to-mesenchymal transitions

Jiri Zavadil  1 , Erwin P Böttinger
Affiliations
Review

TGF-beta and epithelial-to-mesenchymal transitions

Jiri Zavadil et al. Oncogene. .

Abstract (V体育安卓版)

Remarkable phenotype plasticity of epithelial cells underlies morphogenesis, epithelial repair and tumor invasiveness. Detailed understanding of the contextual cues and molecular mediators that control epithelial plasticity will be required in order to develop viable therapeutic approaches targeting epithelial-to-mesenchymal transition (EMT), an advanced manifestation of epithelial plasticity VSports手机版. Members of the transforming growth factor (TGF-beta) family of growth factors can initiate and maintain EMT in a variety of biological systems and pathophysiological context by activating major signaling pathways and transcriptional regulators integrated in extensive signaling networks. Here we will review the distinct physiological contexts of EMT and the underlying molecular signaling networks controlled by TGF-beta. .

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