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Comparative Study
. 2005 Jul 1;121(7):1109-21.
doi: 10.1016/j.cell.2005.05.026.

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

Mark J Kiel  1 , Omer H Yilmaz, Toshihide Iwashita, Osman H Yilmaz, Cox Terhorst, Sean J Morrison
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Free article
Comparative Study

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells (VSports注册入口)

VSports手机版 - Mark J Kiel et al. Cell. .
Free article

Abstract

To improve our ability to identify hematopoietic stem cells (HSCs) and their localization in vivo, we compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors (MPPs). Cell surface receptors of the SLAM family, including CD150, CD244, and CD48, were differentially expressed among functionally distinct progenitors. HSCs were highly purified as CD150(+)CD244(-)CD48(-) cells while MPPs were CD244(+)CD150(-)CD48(-) and most restricted progenitors were CD48(+)CD244(+)CD150(-). The primitiveness of hematopoietic progenitors could thus be predicted based on the combination of SLAM family members they expressed. This is the first family of receptors whose combinatorial expression precisely distinguishes stem and progenitor cells. The ability to purify HSCs based on a simple combination of SLAM receptors allowed us to identify HSCs in tissue sections. Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum. HSCs thus occupy multiple niches, including sinusoidal endothelium in diverse tissues. VSports手机版.

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Comment in

  • Stem cell grand SLAM.
    Wagers AJ. Wagers AJ. Cell. 2005 Jul 1;121(7):967-70. doi: 10.1016/j.cell.2005.06.017. Cell. 2005. PMID: 15989946 Review.

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