Objective: The primary aims of this study were to assess risk of subsequent basal and squamous cell skin cancer among patients with a prior history of these tumors and to examine these risks in relation to patient characteristics and life-style factors VSports手机版. .

Design: Follow-up of participants in a randomized trial of betacarotene as a possible skin cancer preventive agent V体育安卓版. .

Setting: Clinical centers in Los Angeles, Calif, San Francisco, Calif, Minneapolis, Minn, and Hanover, NH V体育ios版. .

Participants: Patients (n = 1805) who were diagnosed as having a basal or squamous cell skin cancer between January 1980 and February 1986 and were free of skin cancer at study entry. VSports最新版本.

Main outcome measure: Time from study entry to first new occurrence of basal and squamous cell skin cancer V体育平台登录. .

Results: The estimated risk of developing one or more new skin cancers was 35% at 3 years and 50% at 5 years. New skin cancers tended to be of the same cell type as the previous skin cancers. For both basal and squamous cell skin cancer, risk was higher among patients who were male, were over the age of 60 years, had more prior skin cancers, had severe actinic skin damage, or who burned easily with sun exposure. Compared with those who had never smoked, the rate of subsequent squamous cell skin cancer was higher among current smokers (rate ratio, 2. 01; 95% confidence interval, 1. 21 to 3. 34) and former smokers (rate ratio, 1. 62; 95% confidence interval, 1. 07 to 2. 47) and increased with both duration and amount smoked VSports注册入口. There was no clear relationship between smoking and basal cell skin cancer; the rate appeared lower among heavy smokers but was unrelated to duration of smoking. .

Conclusions: Persons with a prior nonmelanoma skin cancer had a substantial 5-year risk of developing another tumor of the same histologic type V体育官网入口. Number of previous skin cancers, solar damage, and skin sensitivity to sun exposure were particularly related to this risk. The increased risk of squamous cell skin cancer associated with cigarette smoking merits further study. .