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. 2005 Jun;124(6):1318-25.
doi: 10.1111/j.0022-202X.2005.23747.x.

VSports - Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice

Arianna L Kim  1 , Jeffrey M Labasi, Yucui Zhu, Xiuwei Tang, Kim McClure, Christopher A Gabel, Mohammad Athar, David R Bickers
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"V体育安卓版" Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice

V体育ios版 - Arianna L Kim et al. J Invest Dermatol. 2005 Jun.
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  • J Invest Dermatol. 2005 Dec;125(6):1320

"V体育官网" Abstract

The p38 mitogen-activated protein kinase (MAPK) signaling pathway is activated by numerous inflammatory mediators and environmental stresses VSports手机版. We assessed the effects of ultraviolet B (UVB) on the p38 MAPK pathway and determined whether cyclooxygenase (COX)-2 expression is downstream of this kinase in the skin of UVB-irradiated SKH-1 mice. SKH-1 mice were irradiated with a single dose of UVB (360 mJ per cm2), and activation of the epidermal p38 MAPK pathway was assessed. UVB-induced phosphorylation of p38 MAPK occurred in a time-dependent manner. Phosphorylation of MAPK-activated protein kinase-2 (MAPKAPK-2) also was detected and correlated with an increase in its kinase activity. Phosphorylation of heat shock protein 27 (HSP27), a substrate for MAPKAPK-2, also was detected post-irradiation. Oral administration of the p38 inhibitor, SB242235, prior to UVB irradiation, blocked activation of the p38 MAPK cascade, and abolished MAPKAPK-2 kinase activity and phosphorylation of HSP27. Moreover, SB242235 inhibited expression of the pro-inflammatory cytokines interleukin (IL)-6 and KC (murine IL-8) and COX-2. Our data demonstrate that UVB irradiation of murine skin activates epidermal p38 MAPK signaling and induces a local pro-inflammatory response. Blockade of the p38 MAPK pathway may offer an effective approach to reducing or preventing skin damage resulting from acute solar radiation. .

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