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Review
. 2005 Apr;5(4):284-95.
doi: 10.1038/nri1591.

TEC-family kinases: regulators of T-helper-cell differentiation

Pamela L Schwartzberg  1 , Lisa D Finkelstein, Julie A Readinger
Affiliations
Review

TEC-family kinases: regulators of T-helper-cell differentiation

"V体育2025版" Pamela L Schwartzberg et al. Nat Rev Immunol. 2005 Apr.

Abstract

The TEC-family protein tyrosine kinases ITK, RLK and TEC have been identified as key components of T-cell-receptor signalling that contribute to the regulation of phospholipase C-gamma, the mobilization of Ca(2+) and the activation of mitogen-activated protein kinases VSports手机版. Recent data also show that TEC kinases contribute to T-cell-receptor-driven actin reorganization and cell polarization, which are required for productive T-cell activation. Functional studies have implicated TEC kinases as important mediators of pathways that control the differentiation of CD4(+) T helper cells. Here, we review studies of signalling pathways that involve TEC kinases and how these pathways might contribute to the regulation of T-helper-cell differentiation and function. .

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