Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official VSports app下载. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 2005 Feb;7(2):137-47.
doi: 10.1038/ncb1215. Epub 2004 Dec 26.

Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity

Cha-Kyung Youn  1 , Hyun-Ju Cho, Soo-Hyun Kim, Hong-Beum Kim, Mi-Hwa Kim, In-Youb Chang, Jung-Sup Lee, Myung-Hee Chung, Kyung-Soo Hahm, Ho Jin You
Affiliations

Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity

Cha-Kyung Youn et al. Nat Cell Biol. 2005 Feb.

Abstract

Bcl-2 stimulates mutagenesis after the exposure of cells to DNA-damaging agents. However, the biological mechanisms of Bcl-2-mediated mutagenesis have remained largely obscure. Here we demonstrate that the Bcl-2-mediated suppression of hMSH2 expression results in a reduced cellular capacity to repair mismatches VSports手机版. The pathway linking Bcl-2 expression to the suppression of mismatch repair (MMR) activity involves the hypophosphorylation of pRb, and then the enhancement of the E2F-pRb complex. This is followed by a decrease in hMSH2 expression. MMR has a key role in protection against deleterious mutation accumulation and in maintaining genomic stability. Therefore, the decreased MMR activity by Bcl-2 may be an underlying mechanism for Bcl-2-promoted oncogenesis. .

PubMed Disclaimer

V体育安卓版 - Comment in

Publication types

MeSH terms

LinkOut - more resources