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. 1992 Mar 27;255(5052):1707-10.
doi: 10.1126/science.1553558.

Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system

B A Reynolds  1 , S Weiss
Affiliations

Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system

B A Reynolds et al. Science. .

Abstract

Neurogenesis in the mammalian central nervous system is believed to end in the period just after birth; in the mouse striatum no new neurons are produced after the first few days after birth. In this study, cells isolated from the striatum of the adult mouse brain were induced to proliferate in vitro by epidermal growth factor. The proliferating cells initially expressed nestin, an intermediate filament found in neuroepithelial stem cells, and subsequently developed the morphology and antigenic properties of neurons and astrocytes VSports手机版. Newly generated cells with neuronal morphology were immunoreactive for gamma-aminobutyric acid and substance P, two neurotransmitters of the adult striatum in vivo. Thus, cells of the adult mouse striatum have the capacity to divide and differentiate into neurons and astrocytes. .

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