"V体育官网入口" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 2004 Dec 16;432(7019):917-21.
doi: 10.1038/nature03104. Epub 2004 Nov 7.

Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

Trude H Flo  1 , Kelly D Smith, Shintaro Sato, David J Rodriguez, Margaret A Holmes, Roland K Strong, Shizuo Akira, Alan Aderem
Affiliations
Free article

Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron (V体育官网)

Trude H Flo et al. Nature. .
Free article

Abstract

Although iron is required to sustain life, its free concentration and metabolism have to be tightly regulated. This is achieved through a variety of iron-binding proteins including transferrin and ferritin VSports手机版. During infection, bacteria acquire much of their iron from the host by synthesizing siderophores that scavenge iron and transport it into the pathogen. We recently demonstrated that enterochelin, a bacterial catecholate siderophore, binds to the host protein lipocalin 2 (ref. 5). Here, we show that this event is pivotal in the innate immune response to bacterial infection. Upon encountering invading bacteria the Toll-like receptors on immune cells stimulate the transcription, translation and secretion of lipocalin 2; secreted lipocalin 2 then limits bacterial growth by sequestrating the iron-laden siderophore. Our finding represents a new component of the innate immune system and the acute phase response to infection. .

PubMed Disclaimer

Comment in

  • Cell biology: iron thievery.
    Barasch J, Mori K. Barasch J, et al. Nature. 2004 Dec 16;432(7019):811-3. doi: 10.1038/432811a. Nature. 2004. PMID: 15602535 No abstract available.

Publication types

MeSH terms