Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. VSports app下载.

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2004 Oct 15;306(5695):457-61.
doi: 10.1126/science.1103160.

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

Umut Ozcan  1 , Qiong Cao, Erkan Yilmaz, Ann-Hwee Lee, Neal N Iwakoshi, Esra Ozdelen, Gürol Tuncman, Cem Görgün, Laurie H Glimcher, Gökhan S Hotamisligil
Affiliations

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

Umut Ozcan et al. Science. .

V体育安卓版 - Abstract

Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, we show that obesity causes endoplasmic reticulum (ER) stress VSports手机版. This stress in turn leads to suppression of insulin receptor signaling through hyperactivation of c-Jun N-terminal kinase (JNK) and subsequent serine phosphorylation of insulin receptor substrate-1 (IRS-1). Mice deficient in X-box-binding protein-1 (XBP-1), a transcription factor that modulates the ER stress response, develop insulin resistance. These findings demonstrate that ER stress is a central feature of peripheral insulin resistance and type 2 diabetes at the molecular, cellular, and organismal levels. Pharmacologic manipulation of this pathway may offer novel opportunities for treating these common diseases. .

PubMed Disclaimer

Comment in

"V体育官网" Publication types

MeSH terms

Substances