Objective: To measure products of free radical damage in childhood obesity VSports手机版. .

Methods: Plasma free radicals were assayed in 24 children with exogenous obesity and 24 non-obese healthy controls. A new colorimetric method was used that measures the generation of peroxy radicals (D-Roms), first products of the reaction between free radicals and oxygen V体育安卓版. .

Results: D-Roms levels were higher in the obese children than in the non-obese group (33. 3+/-10. 1 mg% of H2O2 vs 22. 8+/-2. 8 mg% of H2O2; p <0. 001). Moreover, D-Roms levels were higher in children with hyperlipidemia than in children with normolipidemia (49. 6+/-3. 1 mg% of H2O2 vs 27. 8+/-3. 2 mg% of H2O2; p <0. 001). D-Roms level was positively correlated with waist-hip ratio, serum total cholesterol, serum triglycerides, serum low-density lipoprotein-cholesterol, systolic blood pressure, diastolic blood pressure and fasting blood glucose in obese children. In a multivariate regression model for obese children, the independent correlates for D-Roms level were systolic blood pressure (p <0. 001) and serum total cholesterol (p <0 V体育ios版. 001), with the total variance explained being 82%. .

Conclusion: Our study demonstrates for the first time that there was increased D-Roms levels in obese children and adolescents and suggests that increased systolic blood pressure associated with hyperlipidemia may independently contribute to increased oxidative stress in childhood obesity. VSports最新版本.