Background: Intervention studies in microalbuminuric type 2 diabetic patients have demonstrated that it is possible to avoid progression to overt diabetic nephropathy and even to achieve regression to normoalbuminuria. However, the long-term impact of stabilization/regression in albuminuria on decline in glomerular filtration rate (GFR) has not been established. VSports手机版.

Methods: 151 patients with type 2 diabetes and microalbuminuria at baseline in whom GFR was measured at least three times during 7. 8 years of follow-up were divided into three groups according to the level of albuminuria during follow-up. Overt nephropathy was diagnosed as a urinary albumin excretion rate (AER) >300 mg/24 h and remission to normoalbuminuria was defined as an AER <30 mg/24 h at the last examination V体育安卓版. .

Results: During follow-up, 46 patients achieved remission to normoalbuminuria, 58 remained microalbuminuric and 47 patients progressed to overt nephropathy. The mean (+/- SE) yearly decline in GFR was lowest (2. 3+/-0. 4 ml/min/year) in patients who obtained remission, in comparison with patients remaining microalbuminuric, in whom the decline was 3. 7+/-0 V体育ios版. 4 ml/min/year, and patients progressing to overt nephropathy, who had a decline in GFR of 5. 4+/-0. 5 ml/min/year (ANOVA, P<0. 001). Start of antihypertensive treatment during follow-up was strongly associated with remission to normoalbuminuria [odds ratio: 2. 32; 95% confidence interval (CI): 1. 09-4. 93] whereas a decrease in HbA(1c) by 1% increased the probability for remission (odds ratio: 1. 48; 95% CI: 1. 11-1. 97). .

Conclusions: Remission to normoalbuminuria was associated with a decreased GFR decline during 7 VSports最新版本. 8 years of follow-up in type 2 diabetic patients with microalbuminuria. Antihypertensive therapy and improved glycaemic control were independent predictors for remission. .