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Review
. 2004 Sep 15;37(6):768-84.
doi: 10.1016/j.freeradbiomed.2004.06.008.

Mitochondrial redox control of matrix metalloproteinases (V体育平台登录)

Kristin K Nelson  1 , J Andres Melendez
Affiliations
Review

Mitochondrial redox control of matrix metalloproteinases

Kristin K Nelson et al. Free Radic Biol Med. .

Abstract

Reactive oxygen species (ROS) are constantly generated in aerobic organisms during normal metabolism and in response to both internal and external stimuli VSports手机版. Imbalances in the production and removal of ROS have been hypothesized to play a causative role in numerous disease pathologies such as cancer, ischemia/reperfusion injury, and degenerative diseases such as photoaging, atherosclerosis, arthritis, and neurodegeneration. A feature often associated with these diseases is a malfunctioning of the connective tissue remodeling process due to increased activity of extracellular matrix-degrading metalloproteinases (MMPs). This review summarizes the evidence that implicates ROS as key regulators of MMP production and the importance of these interactions in disease pathologies. .

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