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. 2004 Jun 15;94(1-2):141-51.
doi: 10.1016/j.imlet.2004.05.003.

V体育官网 - Interferon-gamma is an autocrine mediator for dendritic cell maturation

Jianping Pan  1 , Minghui Zhang, Jianli Wang, Qingqing Wang, Dajing Xia, Wenji Sun, Lihuang Zhang, Hai Yu, Yongjun Liu, Xuetao Cao
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V体育ios版 - Interferon-gamma is an autocrine mediator for dendritic cell maturation

V体育官网入口 - Jianping Pan et al. Immunol Lett. .

V体育ios版 - Abstract

Maturation of dendritic cells (DC) is critical for efficient antigen presentation and initiation of an immune response VSports手机版. Interferon-gamma (IFN-gamma) is an important Th1 cytokine. In this study, we investigated the role of IFN-gamma in DC maturation using either IFN-gamma receptor deficient- or IFN-gamma overexpression-models. We showed that immature DC generated in vitro from bone marrow (BM) progenitor cells produced low level of IFN-gamma. After LPS stimulation, DC produced more IFN-gamma, and IFN-gamma productions were at comparable levels among C57BL/6 mice-derived DC (C57BL/6 DC), wild-type 129 mice-derived DC (129 DC) and IFN-gamma receptor deficient 129 mice-derived DC (IFN-gammaR-/-DC). We found that IFN-gammaR-/-DC exhibited decreased expression of CD54, CD86, reduced capacity to secrete IL-1beta and IL-12p70, and impaired capacity to stimulate alloreactive T cells and to drive Th1 differentiation. Transfection of IFN-gamma gene into DC promoted DC to express higher CD40, CD54, CD80, CD86, CCR7 and I-Ab, secrete more IL-1beta and IL-12p70, and more potently activate both CD4 and CD8 T cells. These data suggest that IFN-gamma signaling pathway is important for the maturation of DC in an autocrine fashion. .

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