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. 2004 Aug 13;279(33):34087-90.
doi: 10.1074/jbc.C400236200. Epub 2004 Jun 24.

An IAP-IAP complex inhibits apoptosis

Takehiko Dohi  1 , Kazuya Okada, Fang Xia, Casey E Wilford, Temesgen Samuel, Kate Welsh, Hiroyouki Marusawa, Hua Zou, Robert Armstrong, Shu-ichi Matsuzawa, Guy S Salvesen, John C Reed, Dario C Altieri
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Free article

An IAP-IAP complex inhibits apoptosis

Takehiko Dohi et al. J Biol Chem. .
Free article

Abstract

Regulators of apoptosis are thought to work in concert, but the molecular interactions of this process are not understood. Here, we show that in response to cell death stimulation, survivin, a member of the inhibitor of apoptosis (IAP) gene family, associates with another IAP protein, XIAP, via conserved baculovirus IAP repeats. Formation of a survivin-XIAP complex promotes increased XIAP stability against ubiquitination/proteasomal destruction and synergistic inhibition of apoptosis, which is abolished in XIAP(-/-) cells. Therefore, orchestration of an IAP-IAP complex regulates apoptosis. VSports手机版.

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