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. 2004 Jun;20(6):747-56.
doi: 10.1016/j.immuni.2004.05.006.

Escape of mutant double-stranded DNA virus from innate immune control

Anthony R French  1 , Jeanette T Pingel, Markus Wagner, Ivan Bubic, Liping Yang, Sungjin Kim, Ulrich Koszinowski, Stipan Jonjic, Wayne M Yokoyama
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Escape of mutant double-stranded DNA virus from innate immune control

Anthony R French et al. Immunity. 2004 Jun.
Free article

V体育2025版 - Abstract

As innate immune system components, natural killer (NK) cells respond rapidly to infections and effectively control replication of pathogens, including murine cytomegalovirus (MCMV), a double-stranded DNA beta-herpesvirus VSports手机版. In the absence of NK cell control, MCMV infection results in early mortality due to uncontrolled viral replication. However, here we show that even in the face of initial NK cell control, there is late recrudescence of disease and mortality in immunodeficient mice due to the outgrowth of MCMV mutants that escape recognition by innate NK cells. These data suggest that viral infections in certain clinical settings also may be due to viral escape from innate immunity. .

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