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. 2004 Oct 1;104(7):2187-93.
doi: 10.1182/blood-2004-03-1040. Epub 2004 Jun 1.

Association of Foxp3 regulatory gene expression with graft-versus-host disease

Yuji Miura  1 , Christopher J Thoburn, Emilie C Bright, Michele L Phelps, Tahiro Shin, Elizabeth C Matsui, William H Matsui, Sally Arai, Ephraim J Fuchs, Georgia B Vogelsang, Richard J Jones, Allan D Hess
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Free article

Association of Foxp3 regulatory gene expression with graft-versus-host disease

Yuji Miura et al. Blood. .
Free article

Abstract (V体育安卓版)

Graft-versus-host disease (GVHD) is characterized by an impairment of mechanisms that underlie the development of immunologic tolerance. Although the cytokine storm associated with GVHD leads to expression of cell surface markers on both effector and regulatory T cells, regulatory CD4+ T cells that play an instrumental role in the maintenance of tolerance appear to uniquely express the Foxp3 transcriptional repressor. Foxp3 mRNA expression was significantly decreased in peripheral blood mononuclear cells from patients with either allogeneic GVHD or autologous GVHD compared with patients without GVHD. Expression of Foxp3 negatively correlated with the severity of GVHD but positively correlated with recent thymic emigrants. The results suggest that defective thymic function contributes to the impaired reconstitution of immune regulatory mechanisms following transplantation VSports手机版. The decrease in regulatory mechanisms after transplantation appears to provide an environment permissive to the development of GVHD. .

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