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. 2004 Apr 16;117(2):211-23.
doi: 10.1016/s0092-8674(04)00298-3.

VSports最新版本 - Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

Joan Seoane  1 , Hong-Van Le, Lijian Shen, Stewart A Anderson, Joan Massagué
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Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

"VSports最新版本" Joan Seoane et al. Cell. .
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Abstract

FoxO Forkhead transcription factors are shown here to act as signal transducers at the confluence of Smad, PI3K, and FoxG1 pathways VSports手机版. Smad proteins activated by TGF-beta form a complex with FoxO proteins to turn on the growth inhibitory gene p21Cip1. This process is negatively controlled by the PI3K pathway, a known inhibitor of FoxO localization in the nucleus, and by the telencephalic development factor FoxG1, which we show binds to FoxO-Smad complexes and blocks p21Cip1 expression. We suggest that the activity of this network confers resistance to TGF-beta-mediated cytostasis during the development of the telencephalic neuroepithelium and in glioblastoma brain tumor cells. .

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