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. 2004 Mar 5;303(5663):1532-5.
doi: 10.1126/science.1092385.

Neutrophil extracellular traps kill bacteria

Volker Brinkmann  1 , Ulrike Reichard, Christian Goosmann, Beatrix Fauler, Yvonne Uhlemann, David S Weiss, Yvette Weinrauch, Arturo Zychlinsky
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Neutrophil extracellular traps kill bacteria

Volker Brinkmann et al. Science. .
Free article

"VSports注册入口" Abstract

Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome. Here, we describe that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria. These neutrophil extracellular traps (NETs) degrade virulence factors and kill bacteria VSports手机版. NETs are abundant in vivo in experimental dysentery and spontaneous human appendicitis, two examples of acute inflammation. NETs appear to be a form of innate response that binds microorganisms, prevents them from spreading, and ensures a high local concentration of antimicrobial agents to degrade virulence factors and kill bacteria. .

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