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. 2004 Feb 15;172(4):2296-306.
doi: 10.4049/jimmunol.172.4.2296.

Reduced thymocyte development in sonic hedgehog knockout embryos

Divya K Shah  1 , Ariadne L Hager-Theodorides, Susan V Outram, Susan E Ross, Alberto Varas, Tessa Crompton
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"V体育2025版" Reduced thymocyte development in sonic hedgehog knockout embryos

Divya K Shah et al. J Immunol. .

V体育ios版 - Abstract

The Hedgehog family of secreted intercellular signaling molecules are regulators of patterning and organogenesis during animal development. In this study we provide genetic evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development. Analysis of Shh(-/-) mouse embryos revealed that Shh regulates fetal thymus cellularity and thymocyte differentiation. Shh is necessary for expansion of CD4(-)CD8(-) double-negative (DN) thymocytes and for efficient transition from the earliest CD44(+)CD25(-) DN population to the subsequent CD44(+)CD25(+) DN population and from DN to CD4(+)CD8(+) double-positive cells VSports手机版. .

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