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. 2003 Dec;50(5):1553-67.
doi: 10.1046/j.1365-2958.2003.03821.x.

"V体育官网" Enteropathogenic and enterohaemorrhagic Escherichia coli deliver a novel effector called Cif, which blocks cell cycle G2/M transition

Olivier Marchès  1 , Terence Neil Ledger, Michèle Boury, Masaru Ohara, Xuanlin Tu, Frédéric Goffaux, Jacques Mainil, Ilan Rosenshine, Motoyuki Sugai, Jean De Rycke, Eric Oswald
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Enteropathogenic and enterohaemorrhagic Escherichia coli deliver a novel effector called Cif, which blocks cell cycle G2/M transition (V体育ios版)

"VSports" Olivier Marchès et al. Mol Microbiol. 2003 Dec.
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Abstract

Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) are closely related pathogens. Both use a type III secretion system (TTSS) encoded by the 'locus of enterocyte effacement' (LEE) to subvert and attach to epithelial cells through the injection of a repertoire of effector molecules. Here, we report the identification of a new TTSS translocated effector molecule called Cif, which blocks cell cycle G2/M transition and induces the formation of stress fibres through the recruitment of focal adhesions. Cif is not encoded by the LEE but by a lambdoid prophage present in EPEC and EHEC. A cif mutant causes localized effacement of microvilli and intimately attaches to the host cell surface, but is defective in the ability to block mitosis. When expressed in TTSS competent LEE-positive pathogens, Cif is injected into the infected epithelial cells VSports手机版. These cells arrested at the G2/M phase displayed accumulation of inactive phosphorylated Cdk1. In conclusion, Cif is a new member of a growing family of bacterial cyclomodulins that subvert the host eukaryotic cell cycle. .

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