The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses
- PMID: 14614851
- DOI: 10.1016/s1074-7613(03)00296-6
V体育官网入口 - The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses
VSports在线直播 - Abstract
Originally the only known heterodimeric cytokine, IL-12 is now part of a family of five cytokines and shares important functions in the regulation of both innate and adaptive immunity with two of them, IL-23 and IL-27 VSports手机版. Although initially these three cytokines were considered to have largely overlapping immunological functions, more recent studies, including two articles in this issue of Immunity (Hamano et al. , 2003; Villarino et al. , 2003), indicate that they mediate complex and well-differentiated functions. .
Comment on (VSports手机版)
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V体育ios版 - The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.Immunity. 2003 Nov;19(5):645-55. doi: 10.1016/s1074-7613(03)00300-5. Immunity. 2003. PMID: 14614852
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WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production.Immunity. 2003 Nov;19(5):657-67. doi: 10.1016/s1074-7613(03)00298-x. Immunity. 2003. PMID: 14614853
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