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. 2003 Dec;5(12):1051-61.
doi: 10.1038/ncb1063. Epub 2003 Nov 9.

Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis (V体育平台登录)

Darren Boehning  1 , Randen L Patterson, Leela Sedaghat, Natalia O Glebova, Tomohiro Kurosaki, Solomon H Snyder
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Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

Darren Boehning et al. Nat Cell Biol. 2003 Dec.

Erratum in

  • Nat Cell Biol. 2004 Jan;6(1):77

Abstract

Mitochondrial cytochrome c release and inositol (1,4,5) trisphosphate receptor (InsP(3)R)-mediated calcium release from the endoplasmic reticulum mediate apoptosis in response to specific stimuli. Here we show that cytochrome c binds to the InsP(3)R during apoptosis. Addition of 1 nM cytochrome c blocks calcium-dependent inhibition of InsP(3)R function VSports手机版. Early in apoptosis, cytochrome c translocates to the endoplasmic reticulum where it selectively binds InsP(3)R, resulting in sustained, oscillatory cytosolic calcium increases. These calcium events are linked to the coordinate release of cytochrome c from all mitochondria. Our findings identify a feed-forward mechanism whereby early cytochrome c release increases InsP(3)R function, resulting in augmented cytochrome c release that amplifies the apoptotic signal. .

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Comment in

  • Calcium orchestrates apoptosis.
    Mattson MP, Chan SL. Mattson MP, et al. Nat Cell Biol. 2003 Dec;5(12):1041-3. doi: 10.1038/ncb1203-1041. Nat Cell Biol. 2003. PMID: 14647298 No abstract available.

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