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. 2003 Aug;17(11):1565-6.
doi: 10.1096/fj.02-1092fje. Epub 2003 Jun 3.

Multiplex stress resistance in cells from long-lived dwarf mice

Shin Murakami  1 , Adam Salmon, Richard A Miller
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VSports注册入口 - Multiplex stress resistance in cells from long-lived dwarf mice

"VSports手机版" Shin Murakami et al. FASEB J. 2003 Aug.
Free article

Abstract

Mutations that extend nematode longevity by interference with IGF-I/insulin sensing pathways also lead to resistance to multiple forms of stress. Here, we report that skin-derived fibroblasts from Snell dwarf mice, already known to show increased longevity and delayed aspects of aging, are resistant to multiple forms of cellular stress, including UV light, heat, paraquat, H2O2, and the toxic metal cadmium VSports手机版. The findings suggest that increases in cellular resistance to stress may mediate extended longevity in mammals. .

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