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. 2003 Jun;18(6):801-11.
doi: 10.1016/s1074-7613(03)00144-4.

Transcriptional regulation of th2 differentiation by inducible costimulator

Roza I Nurieva  1 , Julie Duong, Hiroko Kishikawa, Umberto Dianzani, Jose M Rojo, I cheng Ho, Richard A Flavell, Chen Dong
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Transcriptional regulation of th2 differentiation by inducible costimulator

V体育平台登录 - Roza I Nurieva et al. Immunity. 2003 Jun.
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Abstract

Helper T (Th) cell differentiation is accompanied by complex transcriptional changes. Although costimulatory receptors are important in Th differentiation, the underlying mechanisms are poorly understood. Here we examine the transcriptional mechanisms by which ICOS regulates Th2 differentiation and selective IL-4 expression by effector T cells. We found impaired expression of c-Maf transcription factor functionally associated with the IL-4 defect in ICOS(-/-) cells. c-Maf expression in effector cells was regulated by IL-4 levels during Th differentiation. ICOS costimulation potentiated the T cell receptor (TcR)-mediated initial IL-4 production, possibly through the enhancement of NFATc1 expression VSports手机版. These data indicate that ICOS, by enhancing TcR signals at an early stage of T cell activation, regulates IL-4 transcription and T cell function in effector cells. .

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