Skip to main page content (V体育官网入口)
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or VSports app下载. mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2003 May 15;170(10):5082-8.
doi: 10.4049/jimmunol.170.10.5082.

TNF enhances CD4+ T cell alloproliferation, IFN-gamma responses, and intestinal graft-versus-host disease by IL-12-independent mechanisms (V体育官网)

Geri R Brown  1 , Edward L Lee, Dwain L Thiele
Affiliations

TNF enhances CD4+ T cell alloproliferation, IFN-gamma responses, and intestinal graft-versus-host disease by IL-12-independent mechanisms

Geri R Brown et al. J Immunol. .

Abstract

Inhibition of TNF/TNFR2 interactions ameliorates intestinal graft-vs-host disease (GVHD) and Th1 cytokine responses induced by transfer of B6 CD4(+) spleen cells into irradiated MHC class II disparate B6. C-H-2(bm12) (bm12) x B6 F(1) recipients. The present studies examined whether these effects of TNF are IL-12 dependent. T cell proliferative responses of B6. 129S1-IL-12rb2(tm1Jm) (B6. IL-12R(-/-)) responder spleen cells were found to be comparable to those of control B6 spleen cells. TNF inhibition reduced T cell proliferation and IFN-gamma production in supernatants of MLC using either B6 VSports手机版. IL-12R(-/-) or control B6 responder cells. GVHD induced wasting disease in recipients of B6. IL-12R(-/-) CD4(+) spleen cells that received a TNF inhibitor-encoding adenovirus (5. 4 +/- 6. 5% weight loss (n = 7)) was significantly reduced compared with levels of weight loss observed in recipients that had received a control adenovirus (25. 7 +/- 12. 2% weight loss (n = 11), p = 0. 001). Furthermore, TNF inhibition was associated with a reduction in colonic GVHD scores (p = 0. 039) and in the percentage of the splenic CD4(+) T cells that expressed IFN-gamma (16 vs 6%). These findings indicate that TNF promotes CD4(+) T cell alloproliferation, IFN-gamma responses, and intestinal GVHD by IL-12-independent mechanisms. .

PubMed Disclaimer

Publication types

MeSH terms

Substances (VSports)