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Review
. 2003 May;88(5):375-8.
doi: 10.1136/adc.88.5.375.

Group B streptococcal conjugate vaccines

C J Baker  1 , M S Edwards
Affiliations
Review

Group B streptococcal conjugate vaccines

C J Baker et al. Arch Dis Child. 2003 May.

V体育平台登录 - Abstract

Linkage of bacterial capsular polysaccharides to proteins to create conjugate vaccines has had a dramatic impact on the health of children. Although unconjugated polysaccharides are poorly immunogenic in infants and some older children and adults, their covalent coupling with proteins stimulates T cell dependent antigenic recognition that profoundly enhances immunogenicity. In the decade since the introduction and widespread use of Haemophilus influenzae type b polysaccharide conjugate vaccines in the United States, invasive H influenzae infections have become a rarity in childhood. Similarly, the conjugation of polysaccharides of Streptococcus pneumoniae to a derivative of diphtheria toxoid and the addition of pneumococcal conjugate vaccine to infant immunisation schedules carries with it promise for a similar decline in the incidence of invasive pneumococcal disease in paediatric patients. VSports手机版.

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