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. 2003 Feb 7;299(5608):887-90.
doi: 10.1126/science.1080280.

Myc-induced T cell leukemia in transgenic zebrafish

David M Langenau  1 , David Traver, Adolfo A Ferrando, Jeffery L Kutok, Jon C Aster, John P Kanki, Shuo Lin, Ed Prochownik, Nikolaus S Trede, Leonard I Zon, A Thomas Look
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Myc-induced T cell leukemia in transgenic zebrafish

David M Langenau et al. Science. .

V体育官网 - Abstract

The zebrafish is an attractive model organism for studying cancer development because of its genetic accessibility VSports手机版. Here we describe the induction of clonally derived T cell acute lymphoblastic leukemia in transgenic zebrafish expressing mouse c-myc under control of the zebrafish Rag2 promoter. Visualization of leukemic cells expressing a chimeric transgene encoding Myc fused to green fluorescent protein (GFP) revealed that leukemias arose in the thymus, spread locally into gill arches and retro-orbital soft tissue, and then disseminated into skeletal muscle and abdominal organs. Leukemic cells homed back to the thymus in irradiated fish transplanted with GFP-labeled leukemic lymphoblasts. This transgenic model provides a platform for drug screens and for genetic screens aimed at identifying mutations that suppress or enhance c-myc- induced carcinogenesis. .

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