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. 2003 Jan 1;170(1):10-3.
doi: 10.4049/jimmunol.170.1.10.

VSports手机版 - Cutting edge: identification of the targets of clonal deletion in an unmanipulated thymus

Hyung J Cho  1 , Samuel G Edmondson, Arden D Miller, MacLean Sellars, Shawn T Alexander, Selin Somersan, Jennifer A Punt
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Cutting edge: identification of the targets of clonal deletion in an unmanipulated thymus (VSports注册入口)

Hyung J Cho et al. J Immunol. .

Abstract

Autoreactive thymocytes can be eliminated by clonal deletion during their development in the thymus. The precise developmental stage(s) at which clonal deletion occurs in a normal thymus has been difficult to assess, in large part because of the absence of a specific marker for TCR-mediated apoptosis. In this report, we reveal that Nur77 expression can be used as a specific marker of clonal deletion in an unmanipulated thymus and directly identify TCRintCD4+CD8+ and semimature CD4+CD8- thymocytes as the principal targets of deletion VSports手机版. These data indicate that clonal deletion normally occurs at a relatively late stage of development, as cells mature from CD4+CD8+ thymocytes to single-positive T cells. .

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