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Review
. 2002 Dec;122(6 Suppl):301S-306S.
doi: 10.1378/chest.122.6_suppl.301s.

Animal models of cigarette smoke-induced COPD

Joanne L Wright  1 , Andrew Churg
Affiliations
Review

Animal models of cigarette smoke-induced COPD (VSports app下载)

Joanne L Wright et al. Chest. 2002 Dec.

Abstract

Objectives: To review the animal models of COPD, and to compare these data to those found in humans VSports手机版. .

Results: Smoke-induced animal models can produce emphysema, although the lesions are not generally close mimics of human emphysema, as well as increases in mucous-secreting cells and vascular changes including pulmonary hypertension. There is considerable species-to-species variation in the degree and/or presence of these different abnormalities, so that care has to be used in selecting a species to study. Remarkably little information is available about the biochemical and molecular changes induced by cigarette smoke in animal models V体育安卓版. .

Conclusions: Great insights into the pathology of chronic obstructive lung disease have been made using various animal models V体育ios版. .

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