Background: Gut-derived endotoxin is insufficiently cleared by the diseased liver, and thus, is elevated in plasma of patients with chronic liver disease (CLD). Endotoxin action might be modified by binding to soluble CD14 (sCD14) and lipopolysaccharide-binding protein (LBP), both of which have not yet been sufficiently studied in CLD. VSports手机版.

Methods: Endotoxin, sCD14 and LBP have been determined in peripheral blood of 72 patients and 39 control subjects, and in portal and hepatic venous blood of 12 patients during transjugular intrahepatic portosystemic shunt (TIPS) implantation V体育安卓版. .

Results: Peripheral endotoxin (average 3-fold increased compared to controls), LBP, and sCD14 plasma levels were elevated in chronic liver disease irrespective of Child stage m, preserve/absence of cirrhosis or aetiology. LBP, and sCD14. Furthermore, endotoxin levels in the portal vein (38 V体育ios版. 1 +/- 6. 1 pg/ml) were only slightly elevated compared to the hepatic vein (29. 2 +/- 4. 4 pg/ml), and peripheral endotoxin levels did not increase after TIPS. .

Conclusions: Decreased hepatocellular function rather than hepatic blood shunting might be responsible for endotoxemia VSports最新版本. The elevation in LBP and sCD14 levels may be a consequence of endotoxemia. .