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. 2002 Oct 17;419(6908):734-8.
doi: 10.1038/nature01112.

Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

Veronika Groh  1 , Jennifer Wu, Cassian Yee, Thomas Spies
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Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

"VSports手机版" Veronika Groh et al. Nature. .

V体育2025版 - Abstract

Engagement of the NKG2D receptor by tumour-associated ligands may promote tumour rejection by stimulating innate and adaptive lymphocyte responses. In humans, NKG2D is expressed on most natural killer cells, gammadelta T cells and CD8alphabeta T cells. Ligands of NKG2D include the major histocompatibility complex class I homologues MICA and MICB, which function as signals of cellular stress VSports手机版. These molecules are absent from most cells and tissues but can be induced by viral and bacterial infections and are frequently expressed in epithelial tumours. MIC engagement of NKG2D triggers natural killer cells and costimulates antigen-specific effector T cells. Here we show that binding of MIC induces endocytosis and degradation of NKG2D. Expression of NKG2D is reduced markedly on large numbers of tumour-infiltrating and matched peripheral blood T cells from individuals with cancer. This systemic deficiency is associated with circulating tumour-derived soluble MICA, causing the downregulation of NKG2D and in turn severe impairment of the responsiveness of tumour-antigen-specific effector T cells. This mode of T-cell silencing may promote tumour immune evasion and, by inference, compromise host resistance to infections. .

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V体育ios版 - Comment in

  • Immunology: catch us if you can.
    Yokoyama WM. Yokoyama WM. Nature. 2002 Oct 17;419(6908):679-80. doi: 10.1038/419679a. Nature. 2002. PMID: 12384682 No abstract available.

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