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. 2002 Sep 1;186(5):598-605.
doi: 10.1086/342295. Epub 2002 Jul 29.

"VSports最新版本" Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies

Sophia S Wang  1 , Allan Hildesheim, Xiaojiang Gao, Mark Schiffman, Rolando Herrero, M Concepcion Bratti, Mark E Sherman, Willard A Barnes, Mitchell D Greenberg, Larry McGowan, Rodrigue Mortel, Peter E Schwartz, Richard J Zaino, Andrew G Glass, Robert D Burk, Peter Karacki, Mary Carrington
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Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies

Sophia S Wang et al. J Infect Dis. .

Abstract

To comprehensively explore the relationship between human leukocyte antigen (HLA) class I alleles and cervical neoplasia, a subset of participants from 3 large US and Costa Rican cervix studies were typed for HLA class I alleles. Study subjects were women with cervical cancer or high-grade squamous epithelial lesions (HSILs; n=365) or low-grade squamous epithelial lesions (LSILs; n=275) or who were cytologically normal (control subjects; n=681). Allele-disease associations were assessed by logistic regression analysis. Consistent associations across all studies were observed for HLA-CW*0202 with a combined odds ratio of 0. 53 (95% confidence interval [CI], 0. 29-0. 89) for cancer or HSILs and 0. 58 (95% CI, 0. 37-1. 04) for LSILs, compared with control subjects and adjusted for study. This finding supports the hypothesis that a single allele may be sufficient to confer protection against cervical neoplasia. Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia. VSports手机版.

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  • HLA class I alleles and cervical neoplasia.
    Visser JT, Hoogeboom BN, Reesink-Peters N, Klip H, Hepkema B, van Velde H, van der Zee AG, Daemen T. Visser JT, et al. J Infect Dis. 2003 May 15;187(10):1675-6. doi: 10.1086/374938. J Infect Dis. 2003. PMID: 12721951 No abstract available.

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