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. 2002 Sep;8(9):971-8.
doi: 10.1038/nm746. Epub 2002 Aug 12.

"V体育官网入口" Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells

Shogo Ishiuchi  1 , Keisuke Tsuzuki, Yukari Yoshida, Nobuaki Yamada, Norikazu Hagimura, Haruo Okado, Akiko Miwa, Hideyuki Kurihara, Yoichi Nakazato, Masaru Tamura, Tomio Sasaki, Seiji Ozawa
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Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells

Shogo Ishiuchi et al. Nat Med. 2002 Sep.

Abstract

Glioblastoma multiforme is the most undifferentiated type of brain tumor, and its prognosis is extremely poor. Glioblastoma cells exhibit highly migratory and invasive behavior, which makes surgical intervention unsuccessful VSports手机版. Here, we showed that glioblastoma cells express Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-type glutamate receptors assembled from the GluR1 and/or GluR4 subunits, and that their conversion to Ca(2+)-impermeable receptors by adenovirus-mediated transfer of the GluR2 cDNA inhibited cell locomotion and induced apoptosis. In contrast, overexpression of Ca(2+)-permeable AMPA receptors facilitated migration and proliferation of the tumor cells. These findings indicate that Ca(2+)-permeable AMPA receptors have crucial roles in growth of glioblastoma. Blockage of these Ca(2+)-permeable receptors may be a useful therapeutic strategy for the prevention of glioblastoma invasion. .

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