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. 2002 Jul 19;297(5580):395-400.
doi: 10.1126/science.1070850. Epub 2002 Jun 27.

"V体育官网入口" Systematic identification of pathways that couple cell growth and division in yeast

Paul Jorgensen  1 , Joy L Nishikawa, Bobby-Joe Breitkreutz, Mike Tyers
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"V体育安卓版" Systematic identification of pathways that couple cell growth and division in yeast

Paul Jorgensen et al. Science. .

Abstract

Size homeostasis in budding yeast requires that cells grow to a critical size before commitment to division in the late prereplicative growth phase of the cell cycle, an event termed Start. We determined cell size distributions for the complete set of approximately 6000 Saccharomyces cerevisiae gene deletion strains and identified approximately 500 abnormally small (whi) or large (lge) mutants. Genetic analysis revealed a complex network of newly found factors that govern critical cell size at Start, the most potent of which were Sfp1, Sch9, Cdh1, Prs3, and Whi5. Ribosome biogenesis is intimately linked to cell size through Sfp1, a transcription factor that controls the expression of at least 60 genes implicated in ribosome assembly. Cell growth and division appear to be coupled by multiple conserved mechanisms VSports手机版. .

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Comment in (V体育官网)

  • Cell biology. When wee meets whi.
    Sudbery P. Sudbery P. Science. 2002 Jul 19;297(5580):351-2. doi: 10.1126/science.1073042. Science. 2002. PMID: 12130772 No abstract available.

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