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. 2002 Jul 19;1576(3):341-5.
doi: 10.1016/s0167-4781(02)00281-6.

Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure

Shinji Ito  1 , Toshihiko Fujimori, Yoshihide Hayashizaki, Yo-ichi Nabeshima
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V体育平台登录 - Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure

Shinji Ito et al. Biochim Biophys Acta. .

Abstract

We have identified a novel mouse gene klph (Klotho-LPH related protein; where LPH stands for lactase-phlorizin hydrolase) that encodes a novel mammalian family 1 glycosidase-like protein. KLPH was a putative type I membrane protein that consists of N-terminal signal sequence, glycosidase domain, transmembrane region and short cytoplasmic tail. Despite its overall structural similarity to other family 1 glycosidases, the glutamic acid for the acid-base catalyst was not conserved in this protein VSports手机版. klph mRNA was predominantly expressed in the kidney and skin. Epitope-tagged KLPH was localized to the perinuclear tubular network structure of the endoplasmic reticulum in cultured cells. .

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