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Comparative Study
. 2002 May;16(5):733-44.
doi: 10.1016/s1074-7613(02)00317-5.

"VSports最新版本" Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation

Jinfang Zhu  1 , Liying Guo, Booki Min, Cynthia J Watson, Jane Hu-Li, Howard A Young, Philip N Tsichlis, William E Paul
Affiliations
Free article
Comparative Study

Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation

Jinfang Zhu et al. Immunity. 2002 May.
Free article

Abstract

IL-4 is important in Th2 differentiation and in cell expansion. Stat6 is necessary and sufficient for both functions. Although Gata3 is critical for Th2 polarization, it is not sufficient to mediate IL-4-driven cell expansion. We report that growth factor independent-1 (Gfi-1), a Stat6-dependent transcriptional repressor, strikingly increases Th2 cell expansion by promoting proliferation and preventing apoptosis. Cells infected with a Gfi-1 retrovirus show striking enhancement of IL-2-induced Stat5 phosphorylation and repression of p27(Kip-1) expression, suggesting a potential mechanism for the Gfi-1 growth effect. The synergy of Gfi-1 and Gata3 provides a mechanism through which IL-4 could selectively promote Th2 cell expansion. VSports手机版.

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