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. 2002 May 3;109(3):397-407.
doi: 10.1016/s0092-8674(02)00719-5.

VSports最新版本 - TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization

Pierre Launay  1 , Andrea Fleig, Anne Laure Perraud, Andrew M Scharenberg, Reinhold Penner, Jean Pierre Kinet
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"V体育2025版" TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization

Pierre Launay et al. Cell. .
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Abstract

Calcium-activated nonselective (CAN) cation channels are expressed in various excitable and nonexcitable cells supporting important cellular responses such as neuronal bursting activity, fluid secretion, and cardiac rhythmicity. We have cloned and characterized a second form of TRPM4, TRPM4b, a member of the TRP channel family, as a molecular candidate of a CAN channel. TRPM4b encodes a cation channel of 25 pS unitary conductance that is directly activated by [Ca2+]i with an apparent K(D) of approximately 400 nM. It conducts monovalent cations such as Na+ and K+ without significant permeation of Ca2+. TRPM4b is activated following receptor-mediated Ca2+ mobilization, representing a regulatory mechanism that controls the magnitude of Ca2+ influx by modulating the membrane potential and, with it, the driving force for Ca2+ entry through other Ca2+-permeable pathways. VSports手机版.

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