Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2002 May;32(5):1428-33.
doi: 10.1002/1521-4141(200205)32:5<1428::AID-IMMU1428>3.0.CO;2-0.

IL-4 secreted from individual naive CD4+ T cells acts in an autocrine manner to induce Th2 differentiation

Nancy Noben-Trauth  1 , Jane Hu-Li, William E Paul
Affiliations
Free article

"VSports注册入口" IL-4 secreted from individual naive CD4+ T cells acts in an autocrine manner to induce Th2 differentiation

Nancy Noben-Trauth et al. Eur J Immunol. 2002 May.
Free article

Abstract

Naive CD4(+) T cell populations rapidly produce small amounts of IL-4 in response to T cell receptor-mediated stimulation and may undergo Th2 differentiation without exogenous IL-4. Whether this is due to autocrine IL-4-stimulation or the production of IL-4 by an infrequent naive cell has not been determined. Here we show that single CD4(+) T cells from RAG2-/- T cells receptor transgenic mice primed with their cognate antigen give rise to IL-4-producing cells at a similar frequency whether primed with or without added IL-4, but not if anti-IL-4 is added to the culture VSports手机版. Thus, each founder cell or one or more of its early daughters can produce sufficient IL-4 to drive Th2 differentiation. This indicates that autocrine IL-4 production by naive CD4 T cells can drive the appearance of Th2 cells. .

PubMed Disclaimer

"V体育官网" MeSH terms

V体育安卓版 - Substances

LinkOut - more resources