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. 2002 Apr;32(4):967-71.
doi: 10.1002/1521-4141(200204)32:4<967::AID-IMMU967>3.0.CO;2-6.

Wnt-1 and Wnt-4 regulate thymic cellularity

Thomas Mulroy  1 , Jill A McMahon, Steven J Burakoff, Andrew P McMahon, Jyoti Sen
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"VSports注册入口" Wnt-1 and Wnt-4 regulate thymic cellularity

Thomas Mulroy et al. Eur J Immunol. 2002 Apr.
Free article

"VSports" Abstract

Thymic primordium, formed by cells derived from the endoderm, the ectoderm and the neural crest-derived mesenchyme, receive fetal liver derived lymphoid precursors. Reciprocal cell-cell interactions between thymic stromal cells and lymphoid precursors are critical in the expansion and maturation of thymocytes. Transcription factor TCF-1 is critical for the expansion of thymocytes because deletion of TCF-1 results in a significant decrease in the number of thymocytes without affecting the developmental pattern. In this report we show that Wnt-1 and Wnt-4 are expressed in the thymus and the deletion of Wnt-1 or Wnt-4 result in a substantial decrease in the number of thymocytes without affecting the pattern of maturation VSports手机版. Wnt-1 and Wnt-4 both regulate developing thymocytes because a double deficiency results in a significantly greater decrease of immature and mature thymocytes compared to deficiency in either Wnt-1 or Wnt-4. .

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