Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 2002 Mar;50(3):402-4.
doi: 10.1136/gut.50.3.402.

Serrated adenoma in familial adenomatous polyposis: relation to germline APC gene mutation (VSports app下载)

T Matsumoto  1 , M Iida, Y Kobori, M Mizuno, S Nakamura, K Hizawa, T Yao
Affiliations

Serrated adenoma in familial adenomatous polyposis: relation to germline APC gene mutation

T Matsumoto et al. Gut. 2002 Mar.

VSports - Abstract

Background: Serrated adenoma is a precursor of colorectal cancer. VSports手机版.

Aim: To clarify possible genotype-phenotype correlations of serrated adenomas in familial adenomatous polyposis (FAP). V体育安卓版.

Patients: Eleven patients from eight families with FAP. V体育ios版.

Methods: We performed total colonoscopy with multiple biopsies in patients VSports最新版本. Neoplasia with a serrated glandular structure was regarded as a serrated adenoma. In each patient, germline mutations of the APC gene were determined. Colonic phenotype was compared with germline mutations of the APC gene. .

Results: Serrated adenomas were found in three patients. These patients had macroscopic polyps <100 in number V体育平台登录. Pedigrees with serrated adenomas had the truncating germline APC mutation at codon 161, 332, or 1556 while in the other pedigrees mutations were found between codons 554 and 1324. .

Conclusions: In FAP, serrated adenoma may be a phenotype characteristic of the attenuated form VSports注册入口. .

PubMed Disclaimer

Figures

Figure 1
Figure 1
Histological findings of a serrated adenoma in case No 10. The lesion is composed of epithelial cells of prominent nuclei in serrated grandular structures. These findings are compatible with a serrated adenoma.
Figure 2
Figure 2
Endoscopic findings of a serrated adenoma in case No 10. There is a whitish semipedunculated polyp in the rectum (A). Under chromoscopy, the polyp has a cerebriform surface (B).
See this image and copyright information in PMC

"V体育平台登录" Comment in

References

    1. Longacre TA, Fenoglio-Preiser CM. Mixed hyperplastic adenomatous polyps/serrated adenoma: a distinct form of colorectal neoplasia. Am J Surg Pathol 1990;14:524–37. - PubMed
    1. Yao T, Kouzuki T, Kajiwara M, et al. “Serrated adenoma” of the colorectum with reference to its gastric differentiation and its malignant potential. J Pathol 1999;187:511–17. - PubMed
    1. Iwabuchi M, Sasano H, Hiwatashi N, et al. Serrated adenoma: a clinicopathological, DNA ploidy, and immunohistochemical study. Anticancer Res 2000;20:1141–7. - PubMed
    1. Hiyama T, Yokozaki H, Shimamoto F, et al. Frequent p53 gene mutations in serrated adenomas of the colorectum. J Pathol 1998;186:131–9. - PubMed
    1. Kang M, Mitomi H, Sada M, et al. Ki-67, p53, and Bcl-2 expression of serrated adenomas of the colon. Am J Surg Pathol 1997;21:417–23. - PubMed

MeSH terms

LinkOut - more resources