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Comparative Study
. 2001 Dec;15(6):897-908.
doi: 10.1016/s1074-7613(01)00240-0.

CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain

J Jayawardena-Wolf  1 , K Benlagha, Y H Chiu, R Mehr, A Bendelac
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Free article
Comparative Study

CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain

J Jayawardena-Wolf et al. Immunity. 2001 Dec.
Free article

Abstract (VSports app下载)

Endosomal trafficking is an essential component of the CD1 pathway of lipid antigen presentation to T cells. We demonstrate that CD1d access to endosomal compartments is under dual regulation by an intrinsic tyrosine-based motif, which governs intense recycling between the plasma membrane and the endosome, and by the invariant chain, with which CD1d associates in the endoplasmic reticulum. Both pathways independently enhance antigen presentation to V(alpha)14(+) NKT cells, the main subset of CD1d-restricted T cells VSports手机版. These results reveal the complexity of CD1d trafficking and suggest that the invariant chain was a component of ancestral antigen presentation pathways prior to the evolution of MHC and CD1. .

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