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Review
. 2001 Nov;11(11):S44-51.
doi: 10.1016/s0962-8924(01)02130-4.

TGF-beta signaling in cancer--a double-edged sword

R J Akhurst  1 , R Derynck
Affiliations
Review

TGF-beta signaling in cancer--a double-edged sword

R J Akhurst et al. Trends Cell Biol. 2001 Nov.

"V体育官网" Abstract

Transforming growth factor (TGF) beta1 is a potent growth inhibitor, with tumor-suppressing activity VSports手机版. Cancers are often refractile to this growth inhibition either because of genetic loss of TGF-beta signaling components or, more commonly, because of downstream perturbation of the signaling pathway, such as by Ras activation. Carcinomas often secrete excess TGF-beta1 and respond to it by enhanced invasion and metastasis. Therapeutic approaches should aim to inhibit the TGF-beta-induced invasive phenotype, but also to retain its growth-inhibitory and apoptosis-inducing effects. .

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