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. 2001 Oct 26;294(5543):862-4.
doi: 10.1126/science.1065329.

An extensive class of small RNAs in Caenorhabditis elegans

R C Lee  1 , V Ambros
Affiliations

An extensive class of small RNAs in Caenorhabditis elegans

R C Lee et al. Science. .

Abstract

The lin-4 and let-7 antisense RNAs are temporal regulators that control the timing of developmental events in Caenorhabditis elegans by inhibiting translation of target mRNAs. let-7 RNA is conserved among bilaterian animals, suggesting that this class of small RNAs [microRNAs (miRNAs)] is evolutionarily ancient. Using bioinformatics and cDNA cloning, we found 15 new miRNA genes in C VSports手机版. elegans. Several of these genes express small transcripts that vary in abundance during C. elegans larval development, and three of them have apparent homologs in mammals and/or insects. Small noncoding RNAs of the miRNA class appear to be numerous and diverse. .

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