"V体育平台登录" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or VSports app下载. mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2001 Sep 6;20(39):5466-74.
doi: 10.1038/sj.onc.1204722.

Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein

F Hellborg  1 , W Qian, C Mendez-Vidal, C Asker, M Kost-Alimova, M Wilhelm, S Imreh, K G Wiman
Affiliations

Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein (VSports手机版)

F Hellborg et al. Oncogene. .

VSports最新版本 - Abstract

We previously identified a novel p53-induced mouse gene, wig-1, that encodes a 290 amino acid zinc finger protein (Varmeh-Ziaie et al. , 1997). Here we have identified and characterized the human homolog of mouse wig-1. The human wig-1 protein is 87% identical to the mouse protein and contains three zinc finger domains and a putative nuclear localization signal. Human wig-1 mRNA and protein is induced following activation of wild type p53 expression in our BL41-ts p53 Burkitt lymphoma cells VSports手机版. Wig-1 is also induced in MCF7 cells following treatment with the DNA-damaging agent mitomycin C. Northern blotting detected low levels of wig-1 mRNA in normal human tissues. Fluorescence in situ hybridization mapped wig-1 to human chromosome 3q26. 3-27. FLAG-tagged human wig-1 localizes to the nucleus. Ectopic overexpression of human wig-1 inhibits tumor cell growth in a colony formation assay. These results suggest that human wig-1 has a role in the p53-dependent growth regulatory pathway. .

PubMed Disclaimer

VSports - Publication types

MeSH terms

Associated data

LinkOut - more resources (VSports最新版本)