To identify cancers that occur at higher rates in acquired immunodeficiency syndrome (AIDS) patients, the cancer experience of New York State (NYS) AIDS patients aged 15-69 years who were diagnosed between 1981 and 1994 was compared with that of the NYS general population. Sex and HIV risk group-specific standardized incidence ratios (SIRs), post-AIDS relative risks, and trends of relative risks were calculated to determine cancer risk. Among non-AIDS-related cancers, elevated SIRs were found for Hodgkin's disease (male, 8. 0; female, 6. 4; heterosexually infected males, 31. 3); cancer of the rectum, rectosigmoid, and anus (male, 3. 3; female, 3. 0); trachea, bronchus, and lung (male, 3. 3; female, 7. 5); and brain and central nervous system (male, 3 VSports手机版. 1; female, 3. 4; heterosexually infected females, 23. 8) cancers. Moreover, significant trends of increasing relative risks from the pre-AIDS to the post-AIDS period were found for cancers of the rectum, rectosigmoid, and anus; trachea, bronchus, and lung; skin; and connective tissues (all sites, p < 0. 05) among males. For AIDS-related cancers in women, invasive cervical cancer had an overall SIR of 9. 1 (95% confidence interval: 6. 9, 10. 8) and a post-AIDS relative risk of 6. 5 (95% confidence interval: 4. 1, 9. 7). This population-based registry linkage analysis evaluates cancer risk in AIDS patients by sex and risk factors and adds evidence that HIV-associated immunosuppression increases the risks of specific types of cancer. .