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. 2001 Oct;2(10):947-50.
doi: 10.1038/ni712.

Toll-like receptors control activation of adaptive immune responses

M Schnare  1 , G M Barton, A C Holt, K Takeda, S Akira, R Medzhitov
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"V体育官网入口" Toll-like receptors control activation of adaptive immune responses

M Schnare et al. Nat Immunol. 2001 Oct.

Abstract

Mechanisms that control the activation of antigen-specific immune responses in vivo are poorly understood VSports手机版. It has been suggested that the initiation of adaptive immune responses is controlled by innate immune recognition. Mammalian Toll-like receptors play an essential role in innate immunity by recognizing conserved pathogen-associated molecular patterns and initiating the activation of NF-kappaB and other signaling pathways through the adapter protein, MyD88. Here we show that MyD88-deficient mice have a profound defect in the activation of antigen-specific T helper type 1 (TH1) but not TH2 immune responses. These results suggest that distinct pathways of the innate immune system control activation of the two effector arms of adaptive immunity. .

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