"V体育平台登录" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil VSports app下载. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 2001 Feb;7(1):56-60.
doi: 10.1080/135502801300069692.

Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef and Tat (VSports手机版)

D G Smith  1 , G J Guillemin, L Pemberton, S Kerr, A Nath, G A Smythe, B J Brew
Affiliations

Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef and Tat

D G Smith et al. J Neurovirol. 2001 Feb.

"V体育ios版" Abstract

Activated macrophages produce quinolinic acid (QUIN), a neurotoxin, in several inflammatory brain diseases including AIDS dementia complex. We hypothesized that IL1-beta, IL6, transforming growth factor (TGF-beta2 and platelet activating factor could increase macrophage QUIN production. And that the HIV-1 proteins Nef, Tat and gp41 may also increase synthesis of QUIN by macrophages. At 72 h there were significant increases in QUIN production in the cells stimulated with PAF (914 +/- 50 nM) and Nef (2781 +/- 162 nM), with somewhat less production by Tat stimulation (645 +/- 240 nM). The increases in QUIN production approximated in vitro concentrations of QUIN shown to be neurotoxic and correlated closely with indoleamine 2,3-dioxygenase induction VSports手机版. IL1-beta, IL6, TGF-beta2 and gp41 stimulation produced no significant increase in QUIN production. These results suggest that some of the neurotoxicity of PAF, nef and tat may be mediated by QUIN. .

PubMed Disclaimer

References

    1. AIDS. 1995 Sep;9(9):1001-8 - PubMed
    1. Ann Neurol. 1995 Mar;37(3):373-80 - PubMed
    1. J Neurovirol. 1995 Dec;1(5-6):375-80 - PubMed
    1. Neurology. 1997 Dec;49(6):1671-81 - PubMed
    1. Biochem J. 1996 Dec 1;320 ( Pt 2):595-7 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources (V体育官网入口)