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. 2001 Jul 6;74(1-3):295-302.
doi: 10.1016/s0168-3659(01)00341-8.

"VSports" Development of the polymer micelle carrier system for doxorubicin

T Nakanishi  1 , S Fukushima, K Okamoto, M Suzuki, Y Matsumura, M Yokoyama, T Okano, Y Sakurai, K Kataoka
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V体育官网 - Development of the polymer micelle carrier system for doxorubicin

T Nakanishi et al. J Control Release. .

Abstract

We show the result of pre-clinical study of NK911, a polymeric micelle carrier system for doxorubicin (DOX). The NK911 micelle carrier consists of polyethyleneglycol and conjugated doxorubicin-polyaspartic acid. It has high hydrophobic inner core, and therefore can entrap the sufficient amount of DOX VSports手机版. NK911 has a small particle size of about 40 nm in diameter that accumulates in tumor tissue by EPR effect showing much stronger activity than the free DOX. We plan to perform a clinical trial at National Cancer Center Hospital, Japan from 2001. .

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