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. 2001 Mar 23;291(5512):2413-7.
doi: 10.1126/science.1058867. Epub 2001 Mar 1.

VSports - Preferential localization of effector memory cells in nonlymphoid tissue

D Masopust  1 , V Vezys, A L Marzo, L Lefrançois
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Preferential localization of effector memory cells in nonlymphoid tissue

D Masopust et al. Science. .

"V体育安卓版" Abstract

Many intracellular pathogens infect a broad range of host tissues, but the importance of T cells for immunity in these sites is unclear because most of our understanding of antimicrobial T cell responses comes from analyses of lymphoid tissue VSports手机版. Here, we show that in response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells. Strikingly, CD8 memory T cells isolated from nonlymphoid tissues exhibited effector levels of lytic activity directly ex vivo, in contrast to their splenic counterparts. These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection. .

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