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Review
. 2000 Dec;1(3):199-207.
doi: 10.1038/35043127.

P63 and P73: P53 mimics, menaces and more (V体育2025版)

A Yang  1 , F McKeon
Affiliations
Review

P63 and P73: P53 mimics, menaces and more

A Yang et al. Nat Rev Mol Cell Biol. 2000 Dec.

Abstract

Inactivation of the tumour suppressor p53 is the most common defect in cancer cells. The discovery of its two close relatives, p63 and p73, was therefore both provocative and confounding VSports手机版. Were these new genes tumour suppressors, p53 regulators, or evolutionary spin-offs. Both oncogenic and tumour-suppressor properties have now been attributed to the p53 homologues, perhaps reflecting the complex, often contradictory, protein products encoded by these genes. p63 and p73 are further implicated in many p53-independent pathways, including stem-cell regeneration, neurogenesis and sensory processes. .

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